Decreasing Poly(ADP-ribose) Polymerase activity restores ΔF508 CFTR trafficking

• Main Authors: Suzana Maria Anjos (Author), Renaud eRobert (Author), Daniel Dirck Waller (Author), Donglei eZhang (Author), Haouaria eBalghi (Author), Heidi M. Sampson (Author), Fabiana eCiciriello (Author), Pierre eLesimple (Author), Graeme eCarlile (Author), Julie eGoepp (Author), Jie eLiao (Author), Pasquale eFerraro (Author), Romeo ePhillipe (Author), Francoise eDantzer (Author), John W Hanrahan (Author), David Y. Thomas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Most cystic fibrosis is caused by mutations in CFTR that prevent its trafficking from the ER to the plasma membrane and is associated with exaggerated inflammation, altered metabolism and diminished responses to oxidative stress. PARP-1 is activated by oxidative stress and causes energy depletion an...