SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism

• Main Authors: Masaya Asano (Author), Serika Motoike (Author), Chika Yokota (Author), Naoto Usuki (Author), Hikaru Yamamoto (Author), Tomoaki Urabe (Author), Kazusa Katarao (Author), Izumi Hide (Author), Shigeru Tanaka (Author), Masashi Kawamoto (Author), Masahiro Irifune (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The serotonin transporter (SERT) is functionally regulated via membrane trafficking. Our previous studies have demonstrated that the SERT C-terminal deletion mutant (SERTΔCT) showed a robust decrease in its membrane trafficking and was retained in the endoplasmic reticulum (ER), suggesting that SERT...