Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors

• Main Authors: Ramon Guerra de Oliveira (Author), Fabiana Sélos Guerra (Author), Cláudia dos Santos Mermelstein (Author), Patrícia Dias Fernandes (Author), Isadora Tairinne de Sena Bastos (Author), Fanny Nascimento Costa (Author), Regina Cely Rodrigues Barroso (Author), Fabio Furlan Ferreira (Author), Carlos Alberto Manssour Fraga (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as candidate ROCK inhibitors using the molecular hybridization of the clinically approved drug fasudil (1) and the IKK-β inhibitor LASSBio-1524 (2). Among the synthesized compounds, the N-methylated derivative 11 (...