Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

• Main Authors: Ahmed Hasbi (Author), Melissa L. Perreault (Author), Maurice Y. F. Shen (Author), Theresa Fan (Author), Tuan Nguyen (Author), Mohammed Alijaniaram (Author), Tomek J. Banasikowski (Author), Anthony A. Grace (Author), Brian F. O'Dowd (Author), Paul J. Fletcher (Author), Susan R. George (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...