Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

• Главные авторы: Ahmed Hasbi (Автор), Melissa L. Perreault (Автор), Maurice Y. F. Shen (Автор), Theresa Fan (Автор), Tuan Nguyen (Автор), Mohammed Alijaniaram (Автор), Tomek J. Banasikowski (Автор), Anthony A. Grace (Автор), Brian F. O'Dowd (Автор), Paul J. Fletcher (Автор), Susan R. George (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Предметы: article
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A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...