Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

• Κύριοι συγγραφείς: Ahmed Hasbi (Συγγραφέας), Melissa L. Perreault (Συγγραφέας), Maurice Y. F. Shen (Συγγραφέας), Theresa Fan (Συγγραφέας), Tuan Nguyen (Συγγραφέας), Mohammed Alijaniaram (Συγγραφέας), Tomek J. Banasikowski (Συγγραφέας), Anthony A. Grace (Συγγραφέας), Brian F. O'Dowd (Συγγραφέας), Paul J. Fletcher (Συγγραφέας), Susan R. George (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...