The CDK9 inhibitor enitociclib overcomes resistance to BTK inhibition and CAR-T therapy in mantle cell lymphoma

• Main Authors: Vivian Jiang (Author), William Lee (Author), Tianci Zhang (Author), Alexa Jordan (Author), Fangfang Yan (Author), Qingsong Cai (Author), Joseph McIntosh (Author), Jovanny Vargas (Author), Yang Liu (Author), Michael Wang (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Inhibitors of Bruton's tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL). However, clinical relapses following BTKi and CD19-directed CAR-T treatments...