Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

• Main Authors: Laura E. Schultz (Author), Jeffrey A. Haltom (Author), Maira P. Almeida (Author), Wesley A. Wierson (Author), Staci L. Solin (Author), Trevor J. Weiss (Author), Jordan A. Helmer (Author), Elizabeth J. Sandquist (Author), Heather R. Shive (Author), Maura McGrail (Author)
• Format: Book
• Published: The Company of Biologists, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumors caused by TALEN or CRISPR targeting are histolog...