Transcriptomic changes and gene fusions during the progression from Barrett's esophagus to esophageal adenocarcinoma

• Main Authors: Yusi Fu (Author), Swati Agrawal (Author), Daniel R. Snyder (Author), Shiwei Yin (Author), Na Zhong (Author), James A. Grunkemeyer (Author), Nicholas Dietz (Author), Ryan Corlett (Author), Laura A. Hansen (Author), Al-Refaie Waddah (Author), Kalyana C. Nandipati (Author), Jun Xia (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The incidence of esophageal adenocarcinoma (EAC) has surged by 600% in recent decades, with a dismal 5-year survival rate of just 15%. Barrett's esophagus (BE), affecting about 2% of the population, raises the risk of EAC by 40-fold. Despite this, the transcriptomic changes during the...