Prevention of Asthma Exacerbation in a Mouse Model by Simultaneous Inhibition of NF-κB and STAT6 Activation Using a Chimeric Decoy Strategy

• Hoofdauteurs: Tetsuo Miyake (Auteur), Takashi Miyake (Auteur), Makoto Sakaguchi (Auteur), Hirokazu Nankai (Auteur), Takahiro Nakazawa (Auteur), Ryuichi Morishita (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2018-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Transactivation of inflammatory and immune mediators in asthma is tightly regulated by nuclear factor κB (NF-κB) and signal transducer and activator of transcription 6 (STAT6). Therefore, we investigated the efficacy of simultaneous inhibition of NF-κB and STAT6 using a chimeric decoy strategy to pr...