Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells

• Main Authors: Fah Chueahongthong (Author), Singkome Tima (Author), Sawitree Chiampanichayakul (Author), Pornngarm Dejkriengkraikul (Author), Siriporn Okonogi (Author), Mathurada Sasarom (Author), Soraya Rodwattanagul (Author), Cory Berkland (Author), Songyot Anuchapreeda (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer 407 and CKR- and EVQ-FLT3 peptides were used to formulate Dox-micelles (DMs) and...