A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases

• Main Authors: Angeliki eMavrantoni (Author), Veronika eThallmair (Author), Michael G Leitner (Author), Daniela N Schreiber (Author), Dominik eOliver (Author), Christian R Halaszovich (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage sensitive phosphatases (VSPs), including engineered voltage sensitive PTEN, are excellent tools to rapidly and reversibly alter the phosphoinositide (PI) content of the plasma membrane in vivo and study the tumor suppressor PTEN. However, widespread adoption of these tools is hampered by the...