Discovery of Benzopyrone-Based Candidates as Potential Antimicrobial and Photochemotherapeutic Agents through Inhibition of DNA Gyrase Enzyme B: Design, Synthesis, In Vitro and In Silico Evaluation

• Главные авторы: Akram Abd El-Haleem (Автор), Usama Ammar (Автор), Domiziana Masci (Автор), Sohair El-Ansary (Автор), Doaa Abdel Rahman (Автор), Fatma Abou-Elazm (Автор), Nehad El-Dydamony (Автор)
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• Опубликовано: MDPI AG, 2024-09-01T00:00:00Z.
• Предметы: article
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Bacterial DNA gyrase is considered one of the validated targets for antibacterial drug discovery. Benzopyrones have been reported as promising derivatives that inhibit bacterial DNA gyrase B through competitive binding into the ATP binding site of the B subunit. In this study, we designed and synthe...