Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila

• Main Authors: Di Chen (Author), Xiao Lan (Author), Xiaoming Huang (Author), Jieqing Huang (Author), Xiaojing Zhou (Author), Zhichao Miao (Author), Yuting Ma (Author), Akira Goto (Author), Shanming Ji (Author), Jules A. Hoffmann (Author)
• Format: Book
• Published: Karger Publishers, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have injected dish-cultured oncogenic RasV12 cells into adult male flies and analyzed by single cell transcriptomics their destiny within the host after 11 days. We identified in the preinjection samples and in the 11-day postinjection samples in all 16 clusters of cells, of which 5 disappeared d...