Small Structural Differences in Proline-Rich Decapeptides Have Specific Effects on Oxidative Stress-Induced Neurotoxicity and L-Arginine Generation by Arginosuccinate Synthase

• Main Authors: Carlos Alberto-Silva (Author), Brenda Rufino da Silva (Author), Julio Cezar Araujo da Silva (Author), Felipe Assumpção da Cunha e Silva (Author), Roberto Tadashi Kodama (Author), Wilmar Dias da Silva (Author), Maricilia Silva Costa (Author), Fernanda Calheta Vieira Portaro (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. The proline-rich decapeptide 10c (Bj-PRO-10c; ENWPHPQIPP) from the <i>Bothrops jararaca</i> snake modulates argininosuccinate synthetase (AsS) activity to stimulate L-arginine metabolite production and neuroprotection in the SH-SY5Y cell line. The relationships between stru...