Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway

• Prif Awduron: Qiongqiong Cao (Awdur), Dongmei Xu (Awdur), Yong Chen (Awdur), Yueming Long (Awdur), Fang Dai (Awdur), Li Gui (Awdur), Yunxia Lu (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Pynciau: article
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Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (D...