Relationship Between PIK3CA Amplification and P110α and CD34 Tissue Expression as Angiogenesis Markers in Iranian Women with Sporadic Breast Cancer

• Main Authors: Shadi Hosseini (Author), Farkhondeh Behjati (Author), Maryam Rahimi (Author), Nazanin Taheri (Author), Hamid Reza Khorram Khorshid (Author), Fatemehte Aghakhani Moghaddam (Author), Saghar Ghasemi Frouzabadi (Author), Masoud Karimlou (Author), Fereidoon Sirati (Author), Elahe Keyhani (Author)
• Format: Book
• Published: Iranian Society of Pathology, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective: The PI3K/AKT/mTOR pathway is known to play an important role in regulating angiogenesis both in normal and breast cancer (BC) tissues. PIK3CA amplification was reported in various malignancies, including approximately 10% of BC cases. The aim of this study was to identify t...