Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne

• প্রধান লেখক: Masutaka Furue (লেখক), Yoko Fuyuno (লেখক), Chikage Mitoma (লেখক), Hiroshi Uchi (লেখক), Gaku Tsuji (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2018-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-eryth...