Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus

• Main Authors: Shunpei Moriya (Author), Hitoshi Takahashi (Author), Daiki Masukawa (Author), Makiko Yamada (Author), Jun Ishigooka (Author), Katsuji Nishimura (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The orexinergic system plays a significant role in regulating proper sleep/wake maintenance. Dual orexin receptor antagonist (DORA) is widely prescribed for insomnia symptoms. The antagonist acts on orexin 1 and 2 receptors located in certain brain areas, including the locus coeruleus and dorsal rap...