Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner.

• Main Authors: Kumar Abhishek (Author), Sushmita Das (Author), Ashish Kumar (Author), Ajay Kumar (Author), Vinod Kumar (Author), Savita Saini (Author), Abhishek Mandal (Author), Sudha Verma (Author), Manjay Kumar (Author), Pradeep Das (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Endoplasmic reticulum (ER) stress generated unfolded stress response (UPR) is a basic survival mechanism which protects cell under unfavourable conditions. Leishmania parasite modulates host macrophages in various ways to ensure its survival. Modulation of PI3K-Akt pathway in delayed apop...