Striatal Dopamine D2-Muscarinic Acetylcholine M1 Receptor-Receptor Interaction in a Model of Movement Disorders

• Main Authors: René A. J. Crans (Author), Elise Wouters (Author), Marta Valle-León (Author), Jaume Taura (Author), Caio M. Massari (Author), Víctor Fernández-Dueñas (Author), Christophe P. Stove (Author), Francisco Ciruela (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. In parallel to dopaminergic denervation, there is an increase of acetylcholine within the striatum, res...