Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?

• Main Authors: R Alan Wilson (Author), Jan A M Langermans (Author), Govert J van Dam (Author), Richard A Vervenne (Author), Stephanie L Hall (Author), William C Borges (Author), Gary P Dillon (Author), Alan W Thomas (Author), Patricia S Coulson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among animal models of schistosomiasis, the rhesus macaque is unique in that an infection establishes but egg excretion rapidly diminishes, potentially due to loss of adult worms from the portal system via shunts or death by immune attack.To investigate this, six rhesus macaques were exposed to Schi...