Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models

• Main Authors: Evelyne J. Demkes (Author), Steven Wenker (Author), Max J. M. Silvis (Author), Martijn M. J. van Nieuwburg (Author), M. Joyce Visser (Author), Marlijn S. Jansen (Author), Maike A. D. Brans (Author), Evelyn Velema (Author), Joost P. G. Sluijter (Author), Imo E. Hoefer (Author), Dominique P. V. de Kleijn (Author), Leo Timmers (Author), Saskia C. A. de Jager (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ischemia-reperfusion and cardiac remodeling is associated with cardiomyocyte death, excessive fibrosis formation, and functional decline, eventually resulting in heart failure (HF). Glucagon-like peptide (GLP)-1 agonists are reported to reduce apoptosis and myocardial infarct size after...