Root Extract of Polygonum cuspidatum Siebold & Zucc. Ameliorates DSS-Induced Ulcerative Colitis by Affecting NF-kappaB Signaling Pathway in a Mouse Model via Synergistic Effects of Polydatin, Resveratrol, and Emodin

• Main Authors: Baohai Liu (Author), Shuangdi Li (Author), Xiaodan Sui (Author), Lianyi Guo (Author), Xingmei Liu (Author), Hongmei Li (Author), Leming Gao (Author), Shusheng Cai (Author), Yanrong Li (Author), Tingting Wang (Author), Xuehua Piao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background:Polygonum cuspidatum Siebold & Zucc. (PCS) has antibacterial properties and may prevent Ulcerative colitis (UC) but related molecular mechanism remains unknown. NF-κB signaling pathway is associated with inflammatory responses and its inactivation may be critical for effective therapy...