Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathway

• Main Authors: Shaoshao Zhang (Author), Leilei Fan (Author), Yongjun Wang (Author), Jianjun Xu (Author), Qiang Shen (Author), Jianhua Xie (Author), Zhipeng Zeng (Author), Tingwen Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Calcific aortic valve disease (CAVD) is a chronic cardiovascular disease with high morbidity that lacks effective pharmacotherapeutics. As a natural flavonoid extracted from Ampelopsis grossedentata, dihydromyricetin (DHM) has been shown to be effective in protecting against atherosclerosis; y...