Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System

• Main Authors: Xiao-Jing Ji (Author), Ji-Wei Hao (Author), Guang-Lei Li (Author), Ning Dong (Author), Xin-Qi Wang (Author), Min Zhou (Author), Qing-Hong Zhang (Author), Yong-Ming Yao (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Although glucagon-like peptide 1- (GLP-1-) based therapy of hyperglycemia in burn injury has shown great potential in clinical trials, its safety is seldom evaluated. We hypothesize that exendin-4, a GLP-1 analogue, might affect the immune response via the activation of the sympathetic n...