Short-Term Celecoxib Promotes Bone Formation without Compromising Cefazolin Efficacy in an Early Orthopaedic Device-Related Infection: Evidence from a Rat Model

• Main Authors: Vuyisa Siphelele Mdingi (Author), Lena Gens (Author), Karen Mys (Author), Peter Varga (Author), Stephan Zeiter (Author), Leonard Charles Marais (Author), Robert Geoffrey Richards (Author), Fintan Thomas Moriarty (Author), Marco Chittò (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-steroidal anti-inflammatory drugs (NSAIDs) are crucial components of multimodal analgesia for musculoskeletal injuries, targeting cyclooxygenase (COX) enzymes (COX-1 and/or COX-2 isoenzymes). Concerns exist regarding their potential interference with bone healing and orthopaedic device-related i...