Cationic Peptidomimetic Amphiphiles Having a <i>N</i>-Aryl- or <i>N</i>-Naphthyl-1,2,3-Triazole Core Structure Targeting <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i>: Synthesis, Antibacterial Evaluation, and an In Vivo <i>C. difficile</i> Infection Model

• Main Authors: Muni Kumar Mahadari (Author), Sreenu Jennepalli (Author), Andrew J. Tague (Author), Papanin Putsathit (Author), Melanie L. Hutton (Author), Katherine A. Hammer (Author), Daniel R. Knight (Author), Thomas V. Riley (Author), Dena Lyras (Author), Paul A. Keller (Author), Stephen G. Pyne (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Clostridioides</i> (also known as <i>Clostridium</i>) <i>difficile</i> is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and...