Blockade of IL-17A/IL-17R Pathway Protected Mice from Sepsis-Associated Encephalopathy by Inhibition of Microglia Activation

• Main Authors: Bo Ye (Author), Tianzhu Tao (Author), Andong Zhao (Author), Liyuan Wen (Author), Xiaofei He (Author), Yi Liu (Author), Qiang Fu (Author), Weidong Mi (Author), Jingsheng Lou (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis-associated encephalopathy (SAE) is a poorly understood condition that leads to long-term cognitive impairment and increased mortality in survivors. Recent research revealed that IL-17A/IL-17R might serve as a checkpoint in microglia-mediated neuroinflammation. The present study was designed t...