A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil.

• Main Authors: Piero L Olliaro (Author), Michel T Vaillant (Author), Vincente J Belizario (Author), Nicholas J S Lwambo (Author), Mohamed Ouldabdallahi (Author), Otavio S Pieri (Author), Maria L Amarillo (Author), Godfrey M Kaatano (Author), Mamadou Diaw (Author), Analucia C Domingues (Author), Tereza C Favre (Author), Olivier Lapujade (Author), Fabiana Alves (Author), Lester Chitsulo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Praziquantel at 40 mg/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg/kg is also deployed nationally.Four trial sites in the Philippines, Mauritania, Tanzania and Brazil enrolled 856 patients using a common protocol, who were randomised to receive pra...