Protective Efficacy of Plasmodium vivax Radiation-Attenuated Sporozoites in Colombian Volunteers: A Randomized Controlled Trial.

• Main Authors: Myriam Arévalo-Herrera (Author), Juan M Vásquez-Jiménez (Author), Mary Lopez-Perez (Author), Andrés F Vallejo (Author), Andrés B Amado-Garavito (Author), Nora Céspedes (Author), Angélica Castellanos (Author), Karen Molina (Author), Johanna Trejos (Author), José Oñate (Author), Judith E Epstein (Author), Thomas L Richie (Author), Sócrates Herrera (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunizing human volunteers by mosquito bite with radiation-attenuated Plasmodium falciparum sporozoites (RAS) results in high-level protection against infection. Only two volunteers have been similarly immunized with P. vivax (Pv) RAS, and both were protected. A phase 2 controlled clinical trial wa...