Design, Synthesis, Biological Evaluation and In Silico Studies of Pyrazole-Based NH₂-Acyl Oseltamivir Analogues as Potent Neuraminidase Inhibitors

• Автори: Jiqing Ye (Автор), Lin Lin (Автор), Jinyi Xu (Автор), Paul Kay-sheung Chan (Автор), Xiao Yang (Автор), Cong Ma (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2021-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti-influenza therapy. The 150-cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150-cavity based on the structure information of oselta...