Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats

• Main Authors: Agnieszka Karbownik (Author), Danuta Szkutnik-Fiedler (Author), Andrzej Czyrski (Author), Natalia Kostewicz (Author), Paulina Kaczmarska (Author), Małgorzata Bekier (Author), Joanna Stanisławiak-Rudowicz (Author), Marta Karaźniewicz-Łada (Author), Anna Wolc (Author), Franciszek Główka (Author), Edmund Grześkowiak (Author), Edyta Szałek (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tyrosine kinase inhibitor sorafenib is the first-line treatment for patients with hepatocellular carcinoma (HCC), in which hyperlipidemia and type 2 diabetes mellitus (T2DM) may often coexist. Protein transporters like organic cation (OCT) and multidrug and toxin extrusion (MATE) are involved in...