Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.

• Main Authors: Lindsay B Tulloch (Author), Stefanie K Menzies (Author), Andrew L Fraser (Author), Eoin R Gould (Author), Elizabeth F King (Author), Marija K Zacharova (Author), Gordon J Florence (Author), Terry K Smith (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Fag: article
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Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of compound 1, a bis-tetrah...