Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

• Päätekijät: Afrina Raza (Tekijä), Shamil Ashraf (Tekijä), Soofia Nigar (Tekijä), Itimad Abdelsalam Mohamed Ayed (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: ziauddin University, 2024-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT), one of the drug-metabolizing enzymes. This study...