Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

• Asıl Yazarlar: Afrina Raza (Yazar), Shamil Ashraf (Yazar), Soofia Nigar (Yazar), Itimad Abdelsalam Mohamed Ayed (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: ziauddin University, 2024-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT), one of the drug-metabolizing enzymes. This study...