Reduction of GTP Cyclohydrolase I Feedback Regulating Protein Expression by Hydrogen Peroxide in Vascular Endothelial Cells

• Main Authors: Masakazu Ishii (Author), Shunichi Shimizu (Author), Teruaki Wajima (Author), Tamio Hagiwara (Author), Takaharu Negoro (Author), Akira Miyazaki (Author), Takashi Tobe (Author), Yuji Kiuchi (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and GTPCH mRNA levels. The inhibitors of nitric oxid...