Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome

• Main Authors: Elena Zaklyazminskaya (Author), Anna Shestak (Author), Dmitry Podolyak (Author), Vera Komoliatova (Author), Leonid Makarov (Author), Anna Novitskaya (Author), Amiran Revishvili (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia. It is associated with mutations in over 20 genes but only SCN5A is recommended for routine genetic screening. This s...