Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents

• Main Authors: Julia A. Pavlova (Author), Zimfira Z. Khairullina (Author), Andrey G. Tereshchenkov (Author), Pavel A. Nazarov (Author), Dmitrii A. Lukianov (Author), Inna A. Volynkina (Author), Dmitry A. Skvortsov (Author), Gennady I. Makarov (Author), Etna Abad (Author), Somay Y. Murayama (Author), Susumu Kajiwara (Author), Alena Paleskava (Author), Andrey L. Konevega (Author), Yuri N. Antonenko (Author), Alex Lyakhovich (Author), Ilya A. Osterman (Author), Alexey A. Bogdanov (Author), Natalia V. Sumbatyan (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, in continuation of our recent research, we synthesized and studied new chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) and the membrane-penetrating cation triphenylphosphonium (TPP), which are linked by alkyl groups of different lengths. Usi...