Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

• Main Authors: Kaixuan Wang (Author), Hao Lu (Author), Xinmiao Wang (Author), Qingxia Liu (Author), Jinxia Hu (Author), Yao Liu (Author), Meihua Jin (Author), Dexin Kong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cancer effects of the pyruvate kinase (PK) M2 inhibitor...