Interpreting ambiguous 'trace' results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard.

• Main Authors: Michelle N Clements (Author), Christl A Donnelly (Author), Alan Fenwick (Author), Narcis B Kabatereine (Author), Sarah C L Knowles (Author), Aboulaye Meité (Author), Eliézer K N'Goran (Author), Yolisa Nalule (Author), Sarah Nogaro (Author), Anna E Phillips (Author), Edridah Muheki Tukahebwa (Author), Fiona M Fleming (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very s...