IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis

• Main Authors: Kaoru Yamagata (Author), Shingo Nakayamada (Author), Tong Zhang (Author), Anh Phuong Nguyen (Author), Naoyuki Ohkubo (Author), Shigeru Iwata (Author), Shigeaki Kato (Author), Yoshiya Tanaka (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the role of UBASH3A in RA pathogenesis, by assessing the role of super-enhan...