Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice

• Main Authors: Ying Huang (Author), Haiying Hu (Author), Ling Liu (Author), Jing Ye (Author), Zhen Wang (Author), Bin Que (Author), Wenjing Liu (Author), Ying Shi (Author), Tao Zeng (Author), Lei Shi (Author), Qingwei Ji (Author), Chao Chang (Author), Yingzhong Lin (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, thereby playing a critical role in inflammatory and autoimmune dis...