Maternal levels of growth differentiation factor-15 in patients with preeclampsia

• Main Authors: Ilkbal Temel Yuksel (Author), Begum Aydogan Mathyk (Author), Berna Aslan Cetin (Author), Ugur Turhan (Author), Zihniye Gonca Okumus (Author), Gonca Yetkin Yildirim (Author), Deniz Kanber Acar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1064-1955; 1525-6065; 10.1080/10641955.2018.1524477
• Keywords: preeclampsia; growth differentiation factor-15; gdf-15; cytokine; Gynecology and obstetrics; RG1-991
• Source: Hypertension in Pregnancy, Vol 37, Iss 4, Pp 192-196 (2018)

Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits. Results: The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009). Conclusion: Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.