Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

• Main Authors: Sheng Jiang (Author), Shuting Wu (Author), Gan Zhao (Author), Yue He (Author), Linlin Bao (Author), Jiangning Liu (Author), Chuan Qin (Author), Jiawang Hou (Author), Yuan Ding (Author), Alex Cheng (Author), Brian Jiang (Author), John Wu (Author), Jian Yan (Author), Laurent Humeau (Author), Ami Patella (Author), David B. Weiner (Author), Kate Broderick (Author), Bin Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic optimization of Nucleic Acid immunogens is important for potentially improving their immune potency. A COVID-19 DNA vaccine is in phase III clinical trial which is based on a promising highly developable technology platform. Here, we show optimization in mice generating a pGX-9501 DNA vaccin...