Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults

• Main Authors: Wei Yin (Author), Axel Facius (Author), Thomas Wagner (Author), Max Tsai (Author), Mahnaz Asgharnejad (Author), Gëzim Lahu (Author), Majid Vakilynejad (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Soticlestat is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H), which catabolizes cholesterol to 24S‐hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox-Gastaut syndrome treatment. This study aimed to develop a model of...