Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• المؤلفون الرئيسيون: Aya Ihara (مؤلف), Koichiro Wada (مؤلف), Masato Yoneda (مؤلف), Nobutaka Fujisawa (مؤلف), Hirokazu Takahashi (مؤلف), Atsushi Nakajima (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2007-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...