Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• Autors principals: Aya Ihara (Autor), Koichiro Wada (Autor), Masato Yoneda (Autor), Nobutaka Fujisawa (Autor), Hirokazu Takahashi (Autor), Atsushi Nakajima (Autor)
• Format: Llibre
• Publicat: Elsevier, 2007-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...