Biochemical diversity in the Trypanosoma congolense trans-sialidase family.

• Main Authors: Thaddeus T Gbem (Author), Mario Waespy (Author), Bettina Hesse (Author), Frank Dietz (Author), Joel Smith (Author), Gloria D Chechet (Author), Jonathan A Nok (Author), Sørge Kelm (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trans-sialidases are key enzymes in the life cycle of African trypanosomes in both, mammalian host and insect vector and have been associated with the disease trypanosomiasis, namely sleeping sickness and nagana. Besides the previously reported TconTS1, we have identified three additional active tra...