The Complex Relationship between Diabetic Retinopathy and High-Mobility Group Box: A Review of Molecular Pathways and Therapeutic Strategies

• Main Authors: Marcella Nebbioso (Author), Alessandro Lambiase (Author), Marta Armentano (Author), Giosuè Tucciarone (Author), Vincenza Bonfiglio (Author), Rocco Plateroti (Author), Ludovico Alisi (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-mobility group box 1 (HMGB1) is a protein that is part of a larger family of non-histone nuclear proteins. HMGB1 is a ubiquitary protein with different isoforms, linked to numerous physiological and pathological pathways. HMGB1 is involved in cytokine and chemokine release, leukocyte activation...