Dynamic regulation of phosphorylation of NMDA receptor GluN2B subunit tyrosine residues mediates ketamine rapid antidepressant effects

• Автори: Ke Wang (Автор), Xuan Tan (Автор), Kai-Mo Ding (Автор), Xue-Zhu Feng (Автор), Yu-Yu Zhao (Автор), Wei-Li Zhu (Автор), Guo-Hai Li (Автор), Su-Xia Li (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2024-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The rapid antidepressant effects of ketamine depend on the N-methyl-D-aspartate (NMDA) receptor containing 2B subunit (NR2B), whose function is influenced by its phosphorylated regulation and distribution within and outside synapses. It remains unclear if ketamine's rapid onset of antidepressan...