Dynamic regulation of phosphorylation of NMDA receptor GluN2B subunit tyrosine residues mediates ketamine rapid antidepressant effects

• Main Authors: Ke Wang (Author), Xuan Tan (Author), Kai-Mo Ding (Author), Xue-Zhu Feng (Author), Yu-Yu Zhao (Author), Wei-Li Zhu (Author), Guo-Hai Li (Author), Su-Xia Li (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rapid antidepressant effects of ketamine depend on the N-methyl-D-aspartate (NMDA) receptor containing 2B subunit (NR2B), whose function is influenced by its phosphorylated regulation and distribution within and outside synapses. It remains unclear if ketamine's rapid onset of antidepressan...