Targeting the gram-negative bacteria peptidoglycan synthase MraY as a new approach for monoclonal antibody anti-bacterial activity

• Main Authors: Jun Cao (Author), Fei Yi (Author), Qiufeng Tian (Author), Guanghui Dang (Author), Wei Si (Author), Siguo Liu (Author), Shenye Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of antibiotics to target bacteria is a well-validated approach for controlling infections in animals and humans. Peptidoglycan biosynthesis is a crucial process in bacteria, and the conserved peptidoglycan synthase MraY is an attractive target for drug design. However, due to the lack of det...