Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

• Main Authors: Menglu Chen (Author), Lei Gao (Author), Pan Chen (Author), Dandan Feng (Author), Yalin Jiang (Author), Yongchao Chang (Author), Jianjun Jin (Author), Fong-Fong Chu (Author), Qiang Gao (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims. To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-ind...